On Sunday these two teams will battle it out to go through to the quater-finals,which would be Manchester United best run in the competition.
Manchester United are set to be the favourites to win this one as they currently sit top of the Women’s Super League table with 32 points only one point clear of last years title winners Chelsea.
Where as Durham are eighth in the Women’s Championship with 15 points.
Marc Skinner the Manchester United manager is excited to welcome back the international players in the squad.
Skinner also made two signings in January who are yet to have minutes on the pitch Jayde Riviere and Lisa Naalsund who are working hard behind to make there debuts.
The last game before the international break saw United pick up a massive three points away to Tottenham. Now they are five games unbeaten.
A stand out player for Manchester United last month was Hannah Blundell who was nominated for player of the month but missed out to Gabby George, who plays for Everton.
For the away team there recent form is a narrow 1-0 lost to Crystal Palace in the Championship before international break. Previous to that they had only been beaten once in five matches since the mid-season.
Despite not being in the same league, these two teams have met five times in the past both of the two games which have come in the past two season have ended 2-2.
Eight other games are going ahead this weekend in this competition the only other North West team playing is Bristol City v Manchester City which kicks off at 15:00 GMT.